Dr. Li is a full member of the Indiana University Cancer Center. The laboratory is focused on research and training in pharmacokinetics, pharmacogenetics, and system biology. Our pharmacokinetics research covers statistical and computational method and tool development for physiologically based pharmacokinetics model for drug-drug interaction prediction, pharmacokinetics/pharmacodynamics model based trial simulation and study design, and pharmacology data mining. Our pharmacogenetics research focuses on bioinformatical and statistical method and tool development for pharmacology functional and genetic variation definition of drug metabolic enzymes, transporters, and drug targets; and their associations with intermediate biomarkers and clinical outcomes. Our system biology research focuses on bioinformatical and computational method and tool development for estrogen metabolic pathway and estrogen regulation pathway. We currently are developing an integrated system consists of SNPs, gene expression, DNA methylation, histone modifications, transcription regulation, microRNA, and estrogen metabolites.