Laboratory of Computational Genomics

Our laboratory is interested in studying regulatory mechanisms of gene expression from different levels, including transcriptional regulation, post-transcriptional regulation, and epigenetic regulation. 

• MotifModeler (identification of cis-acting DNA elements from array-derived gene expression data)
• Microarray data analysis
• Transcriptional regulatory network
• ChIP-seq/ChIP-chip data analysis

• MotifModeler II (identification of transcription factor and microRNA from array-derived gene expression data)
• miR2Disease (curated microRNA-disease database, in collaboration with Harbin Institute of Technology)
• CLIP-seq data analylsis (genome-wide binding landscape of RNA-binding protein)
• SplicingModeler (identification of splicing regulatory factors from genome-wide alternative splicing patterns)

• DNA methylation (MeDIP-chip data analysis)
• MethylModeler (understand the effect of DNA methylation on gene expression)
• Histone modification (ChIP-seq data analysis)